Blood samples (5 mL) were collected at the beginning and at end of the study during the 12-hour fasting condition. The samples were centrifuged at a low level and serum was separated. Biochemical measurements were performed immediately after sampling. Fasting blood sugar (FBS), high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), triglycerides (TG), and TC were measured by an auto-analyzer (Hitachi, USA). The Friedewald formula was used to calculate LDL levels. Fasting serum insulin concentration was measured by enzyme linked immunosorbent assay (ELISA) kits (Mercodia). The homeostatic model assessment (HOMA) was calculated with the formula: HOMA-IR = [FBS (mg/dL)*FINS (μU/mL)] / 405. (23). Quantitative insulin sensitivity check index (QUICKI) was calculated on the basis of suggested formulas: 1 / [log (Insulin μU/mL) + log (Glucose mg/dL)]. (24). The HOMA-B (pancreatic beta cell function) was computed as follow: 20 × FINS (μIU/mL)/fasting glucose (mmol/mL)-3.5. Insulin sensitivity was derived using the formula: HOMA-S (insulin sensitivity) = 22.5/(insulin (mU/L) × glucose (mmol/L)). All biochemical assays were performed in duplicates and the mean was calculated for each subject.
Sorry keto -- the Mediterranean diet is king. Endurance athletes and celebrities like LeBron James and the Kardashians have raved about the high-fat, low-carb ketogenic diet -- which was among Google’s most-searched terms this year. But Dr. Louis Aronne, an endocrinologist at NewYork-Presbyterian and Weill Cornell Medicine who runs the Comprehensive Weight Control Center, noted that the Mediterranean diet “is the only diet that has been proven in trials to promote weight loss and reduce the risk of heart attack, stroke and other cardiovascular diseases.” This meal plan includes using olive oil rich in healthy omega-3 fatty acids as your main cooking oil, and loading your plate with fruits and vegetables, whole grains and lean protein like fish and chicken, with the occasional piece of red meat. The American Heart Association recommends a similar diet that emphasizes whole, unprocessed foods, particularly fruits, veggies and whole grains, as well as low-fat dairy products, nuts and legumes, and non-tropical vegetable oils, while reducing salt, sugar and trans fats.
When you’re in a place where eating unhealthy, calorie-dense food has just become a way of life, it’s tough to imagine yourself as anyone else. Yet that didn’t stop “Zeusmeatball” from giving it a go. He went from 534 pounds down to 305, gained some back, and has been on a mission to lose more. Zeusmeatball shares his love of cycling, his quest to eat right and the occasional tidbit about his life in general.
It's a one-time investment you'll never regret. Here's why: Strength training builds lean muscle tissue, which burns more calories — at work or at rest — 24 hours a day, seven days a week. The more lean muscle you have, the faster you'll slim down. How do you start strength training? Try some push-ups or a few squats or lunges. Use your free weights to perform simple bicep curls or tricep pulls right in your home or office. Do these exercises three to four times per week, and you'll soon see a rapid improvement in your physique.
Also, while your menstrual cycle may not affect weight gain or loss, losing or gaining weight can affect your menstrual cycle. Women who lose too much weight or lose weight too quickly may stop having a period, or have irregular periods. Women who have obesity may also have irregular periods. A regular period is a sign of good health. Reaching a healthy weight can help women who have irregular periods to have cycles that are more regular. Learn more in our Menstrual Cycle section.